Troxerutin

Troxerutin is a derivative of the natural bioflavonoid rutin. Troxerutin is found in many plants, and can be easily extracted from Sophora japonica (Japanese pagoda tree). Troxerutin is an antioxidant and has beneficial effects on venous health. Troxerutin is used in the treatment of varicose veins and hemorrhoids.

Aescin and troxerutin as a successful combination for the treatment of inner ear perfusion disturbances.
Phytomedicine. 2008 March. Siegers CP, Syed Ali S, Tegtmeier M. Institute of Experimental and Clinical Pharmacology and Toxicology, University of Luebeck, Ratzeburger Allee 160, D-23538 Luebeck, Germany.
A fixed combination of aescin and troxerutin has been developed for treating inner ear perfusion problems of different etiology. The efficacy of this combination is tested versus pentoxyfyllin in a randomized clinical study as group comparison with 34 patients for each group. The improvement of hearing after 40-44 days of treatment is determined as end point of treatment. Hearing was measured by threshold, whereby a difference of more than 10dB is judged as a significant improvement. After the treatment with the combination of aescin and troxerutin hearing is significantly improved, in 23 of 34 patients the threshold is changed more than 10dB. With pentoxyfyllin hearing is also improved, although to a lesser degree. Both drugs are well tolerated, major adverse drug effects are not observed with either treatment.

Efficacy of troxerutin on streptozotocin-induced rat model in the early stage of diabetic retinopathy.
Arzneimittelforschung. 2005;55(10):573-80. Chung HK, Choi SM, Ahn BO, Kwak HH, Kim JH, Kim WB. Research Institutes of Dong-A Pharmaceutical Company, Kyunggi, Republic of Korea.
The vascular changes associated with early diabetic retinopathy, which include the formation of microaneurysms and acellular capillaries, vessel dilation, vascular endothelial growth factor expression, were investigated experimentally in streptozotocin-induced diabetic rats treated with antioxidants: troxerutin (trihydroxy-ethylrutoside, CAS 7085-55-4), Vaccinium myrtillus, and calcium dobesilate (hydroquinone calcium sulfonate, CAS 20123-80-2). Oxidative stress might be involved in the upregulation of retinal VEGF during early diabetes, and it is likely that troxerutin has comparatively effective antioxidant properties. Therefore, troxerutin might be a useful treatment for attenuating diabetic retinopathy.

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